Role of OX -Notch Signaling in Thymic Treg Development and Homeostasis
Words: 501 Pages: 2 4875Regulatory T cells (Tregs) plays a crucial role in immune tolerance and diminution of their homeostatic balance causes autoimmunity. Tregs are generated in the thymus (Natural Tregs) and contribute a major portion of the peripheral Treg pool where they suppress self-reactive effector T-cell response. Thymic Treg development occurs in two phases i) In TCR-dependent phase where thymocytes expressing high-affinity T-cell Receptors (TCR) give rise to CD4+CD25-FoxP3low and CD4+CD25+FoxP3- Treg progenitors, ii) In the second TCR-independent phase thymic Treg progenitors gain […]