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Mechanism of Action of Artemisia and their Active Ingredients

Words: 1097 Pages: 4 3867

The essential oil is extracted from leaf, areal part, stem and inflorescence of Artemisia by various method, for example, hydro-distillation methods (Pandey, A.K. et al. 2014) . Essential oil is composed of more than 60 different component, the concentration and the composition of essential oil of same species differ related to change in geographical origin. Essential oil contains a major component reported in Artemisia species, such as beta-pinene, thujone, 1, 8-Cineole, camphor, caryophyllene, camphene, artemisia ketone and germacrene D(Chu S, […]

Personalized Medicine in Health Related Industries

Words: 3438 Pages: 11 4535

“In 1997, a Nature Biotechnology article reported how the advances made in genomics have been building a foundation for a future of personalized medicines where produced drugs are focused for the individual rather than the “average person.” Over the years in health related industries, personalized medicine has become a powerful term that brings forth a depiction of a medical revolution that graduates from a “one size fits all” approach to one that factors in predictions of disease, diagnosis and treatment […]

Localization of the MLKL Protein to the Plasma Membrane and how it Affects TNF-induced Necroptosis

Words: 3612 Pages: 12 4014

“In this study, the authors’ main focus is the MLKL protein properties such as; where it is translocated, what it induces upon translocation, and the possible complexes that if forms. The experiment as whole, shows the MLKL becomes phosphorylated by RIP3 and results in an engagement with the necrosome through its interaction with RIP 3. It is demonstrated that MLKL forms a homotrimer and then localizes to the plasma membrane with RIP3 which is required for mediating necroptosis. Interestingly enough, […]

Globular Protein – Caspase-9 Enzyme

Words: 1667 Pages: 6 3875

The globular protein caspase-9 initially many not seem very important or significant; it sounds like the ninth of many other caspase proteins. However, this protein plays a vital role in not only the cell’s life cycle, but the life of humans and other mammals as well. Caspase-9 is an enzyme that’s function ultimately leads to cell degradation and apoptosis. This protein is a member of the peptidase family C14, and is encoded by the CASP9 gene located on the short […]

What is UV Light?

Words: 1463 Pages: 5 4105

“The visual system is arguably the most important sense that humans have in order to navigate the world around them. The eyes are highly susceptible to UV light, making them a prime target for free radical oxidation of both lipids and proteins, causing cell damage and eventually, cell death. One such disease caused by UV light exposure is called age related macular degeneration (AMD), which is the most common cause of blindness in the United States. This disease is complicated […]

Role of P53 Protein in DNA Repair Mechanism

Words: 680 Pages: 2 4236

One of the most known tumor suppressors is p53 which has very low concentration because of short half-life time. Reason for this short half-life is E3 ubiquitin ligase MDM2. MDM2 is one of the genes regulated by transcription which p53 regulates. Increased p53 levels result also increased of MDM2 transcription rate, followed by this, it results the degradation of the p53 protein, forming an autoregulatory circuit in cells. There are various stress situations that can cause this such as telomere […]

The Importance of 3D Models in Initiation Mechanisms

Words: 928 Pages: 3 4184

In the talk given by Dr. Joan Brugge, she discusses progression, drug resistance, and the different aspects in which 3-D models aid in the investigation of cancer biology. Her laboratory has provided wonderful and crucial insights into the understanding and treatment of cancer. Dr. Brugge covered small different ‘contexts’ in which three-dimensional cultures can help in cancer research and protein biochemistry. One of the interests in her laboratory was to research the cellular processes and pathways that mediate alterations that […]