“In ordinary tissues there is a harmony between the age of new cells by means of cell division and the loss of cells by means of cell demise. Old cells progress toward becoming harmed after some time and are wiped out. This is a basic type of recharging. Models incorporate shedding of skin cells and […]
Apoptosis goes on in each living thing. It shapes the beginning life form of every animal and is behind the huge adjustments of caterpillars into butterflies and tadpoles into frogs. Some plant cells moreover deliberately execute themselves, for example, to stop an assaulting parasitic or bacterial tainting spreading. In run of the mill tissues there […]
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Let an Expert Do ItFunction and Structure of PKB PKB contains three isoforms with catalytic domains similar to those in the AGC kinase family. PKB? was initially discovered through homology cloning and the similar appearance of its kinase domain resembled that of protein kinase A and C therefore it was named protein kinase B (PKB). It has two family […]
Apoptosis is an event in which a cell is programmed and specifically sentenced to death. It happens naturally in the body. Apoptosis in greek means to fall off, and that’s one way to think about it. It’s as if one, or a few chosen cells are falling off a cliff, while the rest keep working. […]
There are two well-known methods of cell execution namely: Apoptosis and Necrosis. Whereas necrosis is regarded as a violent form of cell death, apoptosis on the other hand, is a more benign, modulated and rational mode of killing cells which involves making well-informed decisions about selected cells to be terminated for the greater good of […]
Apoptosis is an important cellular process that allows cells to die in a programmed and organized fashion. This form of programmed cell death is crucial to the stability and equilibrium of living organisms. Such a process is shared amongst vertebrates and invertebrates alike (Miguel-Aliaga et al., 2009). It is easiest to define “normal” development by […]
The article under review examines the acceleration of inflammation and growth of prostate tumor metastasis in bone due to apoptosis-induced CXCL5. Tumor cell death, which can be increased by target therapies, causes immense efferocytosis to clear the apoptotic cells. It is thought that this can lead to accelerated tumor growth. The scope of this research […]
All living cells will eventually decay and die. There are two recognized types of cell death: apoptosis and necrosis. Apoptosis refers to the “self-destruction” of a cell by its own mechanisms. Typically, a cell will undergo apoptosis when it is no longer able to repair itself. This could result from a number of possible cell […]
The author declared that diosgenin, restrain STAT3 signaling way leading to inhibition of multiplication and chemosensitization of liver tumor cells (31). Overexpression of active STAT3 release diosgenin tempt apoptosis. Moreover, Diosgenin causes the aggregation of the cells in the G1 stage of the cell cycle and Diosgenin trigger caspase-3 and causes PARP cleavage in HCC […]
“In this presentation, it reviewed some basic concepts regarding the interactions between magnetic nanoparticles and a static or time-varying external magnetic field, and shown how these pertain to current biomedical applications of magnetic nanoparticles. The focus was in particular on magnetic separation, and drug delivery, although these are only two of the many biomedical applications […]
The basic concepts regarding the interactions between magnetic nanoparticles and a static or time-varying external magnetic field were reviewed. How these pertain to current biomedical applications of magnetic nanoparticles were also analyzed. The focus was in particular on magnetic separation and drug delivery. Although these are only two of the many biomedical applications of magnetic […]
Apoptosis is a form of preprogrammed cell death. It can occur if DNA is too damaged or if a cell is infected and cannot complete its function anymore. There are two pathways to trigger cell death. The extrinsic pathway begins the process through external ligand binding. The intrinsic pathway begins by releasing mitochondrial proteins into […]
That Switches TNF-Induced Cell Death from Apoptosis to Necrosis describes steps that led to the discovery of protein kinase receptor-interacting protein 3 (RIP3), a molecular switch that changes TNF-induced cell death from Apoptosis to Necrosis. Necrosis is a caspase independent cell death induced in the presence of caspase inhibitor zVAD and simulation of TNF. Tumor […]
Nanoparticles are particles in the nanosized range (10-9m) that can be made from various materials; this poster will focus specifically on iron oxide nanoparticles (IONs). Due to their small size and unique optical, photochemical, magnetic, and chemical properties, IONs are being used as a new approach in cancer therapy as an alternative to conventional treatments. […]
“In physiological settings, intrinsic genetic programs allow eukaryotic cells to commit suicide in a regulated manner. The best studied programmed cell death is apoptosis which is regulated by cysteine-aspartic proteases called caspases. Apoptosis is crucial for the development of an organism and is immunologically silent due to the containment of intracellular contents which do not […]
Abstract Cancer has been a public health problem that has gained a lot of death. However, in spite of the advances in the diagnosis and treatment of cervical cancer, women follow the struggle versus this disease. Also, those patients suffer from limited efficacy and specificity, undesirable effects, drug resistance, and a high cost of treatments. […]
Bioactive compounds, including polyphenols and phenolic acids or flavonoids, etc., have antioxidant and pro-oxidant properties. These compounds show high specificity because probably they act as an anti-oxidant and pro-oxidant. Approximately 60% of drugs currently used for cancer treatment have been isolated from natural products and the plant kingdom has been the most significant source. These […]
Cancers such as leukemia and lymphoma are hematologic diseases that affect millions of Americans each year. Specifically, acute myeloid leukemia, which is also known as AML, is considered to be one of the most frequently occurring types of leukemia and is a major cause of mortality in the United States. Acute myeloid leukemia is infamous […]
Background Prostate cancer is one of the most common forms of cancer that can metastasize to the bone. The mechanism of how cancer cells break away from their primary origin and travel through the bloodstream to the bone is a process that is still unclear to many scientists (“Bone Metastasis,” 2018). Once cancer cells reach […]
Prostate cancer is one of the most common forms of cancer that can metastasize to the bone. The mechanism of how cancer cells break away from their primary origin and travel through the bloodstream to the bone is a process that is still unclear to many scientists (“Bone Metastasis,” 2018). Once cancer cells reach the […]
Introduction Autophagy is a highly conserved and regulated process that occurs in cells to maintain cellular homeostasis. It is a catalytic process in which cytoplasmic components, such as macromolecules, organelles, and debris, are degraded, thus providing new building block for cellular recycling. Autophagy is also important for promoting cell survival in response to stressful environmental […]
As a treatment of different cancer diseases, chemotherapy and radiotherapy are used on patients. Unfortunately radiotherapy may cause dangerous effects. Investigating these effects and determinations of risk reliable research. It is shown that IR’s most dangerous effect in cells are DBSs and that monitoring ?-H2AX focus numbers were useful biomarker to detect the invidual ionizing […]
The globular protein caspase-9 initially many not seem very important or significant; it sounds like the ninth of many other caspase proteins. However, this protein plays a vital role in not only the cell’s life cycle, but the life of humans and other mammals as well. Caspase-9 is an enzyme that’s function ultimately leads to […]
One of the most known tumor suppressors is p53 which has very low concentration because of short half-life time. Reason for this short half-life is E3 ubiquitin ligase MDM2. MDM2 is one of the genes regulated by transcription which p53 regulates. Increased p53 levels result also increased of MDM2 transcription rate, followed by this, it […]
This paper by Shen and collegues describes the role of the HIF-1 gene and the gene’s response to low oxygen levels in Caenorhabditis elegans (C. elegans). The hypoxia-inducible transcription factor (HIF-1) plays a critical role in being regulating systematic activities. The HIF-1? subunit contains proline residues which, in the presence of high oxygen levels are […]
Significance According to 2018 data, an estimated 609,640 people in the United States will die from cancer this year, while approximately 1.7 million new cases of cancer will be diagnosed1. Cancer is the second leading cause of death in the US and constitutes approximately 22 percent of deaths1. In addition, cancer creates huge financial burdens […]
One of the most leading cause of death globally is cancer and it is responsible for 8.8 million deaths in 2017. It is expected that there would be 70% rise in the number of new cases of cancer in the next two decades. Cancer causes nearly 1 in 6 deaths globally. Cancer is a complex […]
CDH1 CDH1 which is also known as E-cadherin founds on chromosome 16q22.1 and supports cell–cell adhesion by forming adhesive junctions in epithelial cells for inititating and preserving intercellular adhesion, cell polarirty, intercellular signalling and structure of tissue. There have many reports that emphasize on a fact that CDH1 is being expressed in several types of […]
Abstract: Haemoglobinopathies are the commonest single gene disorders in the world, which result in anaemia due to premature destruction of red cells. Defective globin chain renders the cells vulnerable to oxidative damage. Such anaemic state can only be corrected by regular transfusion of blood. The only way to reduce the transfusional load, is through salvaging […]
Estrogen, a steroid hormone, produced by the ovaries, has been the focus of research for its neurobehavioral and physiological properties. Estrogen has many different functions besides its well documented roles in reproductive development and sexual differentiation (Vrtacnik et al 2014). For example, the importance of estrogen becomes apparently clear during menopause when the endogenous levels […]
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