Biology and Signaling Alterations in AD
Words: 1635 Pages: 5 4290The Rho-associated coiled-coil containing kinases (ROCKs) are ubiquitously expressed serine/threonine kinases that are downstream effectors of the RhoA GTPase (Ishizaki et al., 1996b; Leung et al., 1996a; Leung et al., 1995a; Matsui et al., 1996a; Nakagawa et al., 1996a; Schackmann et al., 2011). ROCKs are key regulators of the actomyosin cytoskeleton dynamics, as well as neuronal morphology and synaptic plasticity (Schubert and Dotti, 2007). The two ROCK homologs (ROCK1 and ROCK2) share high homology in their kinase domains (92%) and […]