RIP3, an Energy Metabolism Regulator
Words: 628 Pages: 2 4485That Switches TNF-Induced Cell Death from Apoptosis to Necrosis describes steps that led to the discovery of protein kinase receptor-interacting protein 3 (RIP3), a molecular switch that changes TNF-induced cell death from Apoptosis to Necrosis. Necrosis is a caspase independent cell death induced in the presence of caspase inhibitor zVAD and simulation of TNF. Tumor necrosis factor (TNF) is an inflammatory cytokine that induces necrotic cell death as well as transcription factor activation and inflammatory and immunological responses. It brings […]