Diosgenin in Colon Cancer
Words: 878 Pages: 3 4650The author noted that diosgenin constrains the 3-hydroxy-3-methylglutaryl CoA reductase expression and stimulates apoptosis in human colon tumor cells. Diosgenin is also a potent inhibitor of HCT-116 with growth inhibition and induction of apoptosis [39]. Diosgenin induces apoptosis via the cyclooxygenase-2 and 5-lipoxygenase pathways in HT-29 and HCT-116 [40]. The author described diosgenin's ability to enhance 5-LOX activity; its inhibition by AA-861 notably reduces the apoptosis of colorectal tumor cells. Moreover, colorectal carcinoma cells expressing COX-2 are less sensitive to […]