Cyclic GMP-AMP Synthase
Words: 385 Pages: 1 4984Genomic DNA can be damaged by endogenous or environmental stresses. During repair, these short single-stranded DNAs are continuously generated and may leak out to the cytoplasm, where they are generally drawn back into the nucleus by DNA repair and replication factors (RPA and Rad51). Alongside this, TREX1, a cytoplasmic exonuclease, is anchored on the outer nuclear membrane to degrade leaking DNAs immediately. This prevents activation of the cGAS/STING pathway against self DNA. Inhibition of any of the above-mentioned proteins leads […]