Estrogen, a Steroid Hormone
Words: 246 Pages: 1 4345Our results extend previous observations describing estrogen's neuroprotective effects. A previous study suggested that the sex hormones estrogen and testosterone worked differently as neuroprotective agents. It provided data for a role of testosterone as a neuroprotective hormone in neurons. When looking at how they regulate protease activity, their results show that testosterone and dihydrotestosterone inhibited calpain activation and the generation of the 17-kDa tau fragment, but did not work on caspase-3 activation and tau truncation at Asp421 as estrogen did. […]