Cytotoxic Activity of Aloin
Words: 2929 Pages: 10 4735Abstract In the present study, the cytotoxic activity of aloin, a natural anthraquinone glycoside, was assessed against a breast cancer cell line (T47D) using MTT and clonogenic assays, compared to doxorubicin, an anthracycline analog. The effects of exposure of T47D tumor cells to IC50 values of aloin and doxorubicin (181.5 and 0.17µM, respectively) for 72 h on the mRNA expression levels of a non-receptor tyrosine kinase (JAK-2), a transcription factor (STAT-5a) and some biomarkers for epithelial-mesenchymal transition (EMT) were evaluated. […]